This course is designed to introduce students to recent advances in field molecular toxicology. A basic foundation in genetics and tools of biotechnology will first be developed. Recent examples of innovative approaches used to study toxic agents at molecular level will then be described. Progress in the research of DNA/Protein adducts, xenobiotic metabolism and characterization of oncogenes will also be discussed.

Reviews the basic concepts of epidemiology including community diagnosis, analytical techniques, and evaluation of preventive methods. Examples of both acute and chronic diseases will be covered. Course includes lectures and readings. E-mail is utilized.

The role of chromosome structure and function is presented. Topics covered include cytogenetics methodology, aneuploidy, chromosome rearrangements, chromosomes and cacer, chromosome breakage syndroms, and gragile sites on human chromosomes.

Papers to be selected from current periodicals in the biological sciences for presentation. Emphasis will be placed on a critical evaluation of experimental procedures, data, and the interpretation of data.

An advanced course for those who have a major interest in quantitative aspects of genetics, namely, in the genetic epidemiology of human diseases.

Elective course summarizes the concepts and biological principles underlying bases molecular biomarkers; provide students with understanding methodological principles of use; biomarkers epidemiological research relevant to study of chronic human disease and public health applications; summarize present use of specific biomarkers in epidemiologic and clinical research with examples in human cancer, cardiovascular, immunological, and neurological diseases.

An advanced course which discusses the principles and practice of linkage analysis in human genetics. The course will cover both parametric and non-parametric approaches to linkage analysis, and includes hands-on experience with the current computer programs used for linkage analysis

The topics covered in this course include the electrophysiological analysis of resting and action potentials, a description of both the pre- and postsynaptic ionic mechanisms involved in synaptic transmission, and an overview of specific examples of how the cellular mechanisms described earlier in the course can be integrated ito models of the functioning of small neural networks.

This course is a component of the introductory graduate sequence designed to provide an overview of neuroscience. The course provides an introduction to the structure of the mammalian nervous system and to the functional organization of sensory systems, motor systems, regulatory systems, and systems involved in higher brain functions. It is taught in a lecture format with a lab/conference corequisite (systems NB conference).

Mechanisms and consequence of somatic and hereditary genetic damage, including methods to detect, characterize and quantitate genetics lesions. Provides molecular and theoretical basis for evaluation of genotoxicological date on exposure to mutagenetic/carcinogenic agents and on genetic predisposition or susceptibility to disease.

Vaccines are widely regarded as one of the major contributors to increased life expectancy. The purpose of this course is to (1) explore the history of vaccines; (2) underscore the successful role of current vaccines in the management of infectious disease; (3) present strategies for a new generation of safe and effective molecular vaccines; and (4) discuss the ethical and economic realities of vaccine use and development.

Students will attend lectures on selected topics of current research in the biological sciences. The lecturers will primarily be invited scientists from outside the University, with a few lectures by faculty from within the department or other deparmtnets in the University.

The organic, inorganic and mechanistic biochemical details of interactions of toxins and biological systems will presented. Emphasis on chemical understanding of potential toxicological sequelae of such interactions. Students present one lecture on bioorganic toxicological topic synthesized from recent scientific literature.