The proximal tubule is the only segment of the nephron that can reabsorbed protein and normally, functions so efficiently that urine is protein free. Proteins that are not reabsorbed by the proximal tubule can be toxic and cause damage to more distal parts of the nephron. We know that the uptake of many proteins is mediated by receptors and that the cells can change the amount of protein uptake in response to stimuli. I’m working to develop a model of receptor sorting and recycling in proximal tubule cells. Understanding the regulation of protein reabsorption can guide future research in diseases that cause proximal tubule dysfunction.
Education & Training
- B.S. in Biology, College of William and Mary, VA, 2015
- American Society of Nephrology PreDoctoral Fellowship Award 2017-18