Roderick Tan, M.D., Ph.D.

  • Department of Medicine

Education & Training

  • B.S. Biology, Georgetown University, 1999
  • Ph.D. Cellular and Molecular Pathology, University of Pittsburgh, 2007
  • M.D. Medicine, University of Pittsburgh, 2007

Research Interest Summary

My laboratory is interested in the molecular and cellular mechanisms driving acute and chronic kidney injuries

Research Categories

Representative Publications

Tan RJ, Chartoumpekis DV, Rush BM, Zhou D, Fu H, Kensler TW, Liu Y. Keap1 hypomorphism protects against ischemic and obstructive kidney disease. Sci Rep. 2016 Nov 2;6:36185. doi: 10.1038/srep36185. PMID:27804998

Zhou D, Tian Y, Sun L, Zhou L, Xiao L, Tan RJ, Tian J, Fu H, Hou FF, Liu Y.Matrix Metalloproteinase-7 Is a Urinary Biomarker and Pathogenic Mediator of Kidney Fibrosis. J Am Soc Nephrol. 2017 Feb;28(2):598-611. doi: 10.1681/ASN.2016030354. Epub 2016 Sep 13.PMID:27624489

Fu H, Tian Y, Zhou L, Zhou D, Tan RJ, Stolz DB, Liu Y. Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis.J Am Soc Nephrol. 2017 Mar;28(3):785-801. doi: 10.1681/ASN.2016020165. Epub 2016 Sep 9.PMID:27612995

Zhou L, Mo H, Miao J, Zhou D, Tan RJ, Hou FF, Liu Y. Klotho Ameliorates Kidney Injury and Fibrosis and Normalizes Blood Pressure by Targeting the Renin-Angiotensin System. Am J Pathol. 2015 Dec;185(12):3211-23. doi: 10.1016/j.ajpath.2015.08.004. Epub 2015 Oct 24. PMID:2647541

Xiao L, Zhou D, Tan RJ, Fu H, Zhou L, Hou FF, Liu Y. Sustained Activation of Wnt/β-Catenin Signaling Drives AKI to CKD Progression. J Am Soc Nephrol. 2016 Jun;27(6):1727-40. doi: 10.1681/ASN.2015040449. Epub 2015 Oct 9. PMID: 26453613

Tan RJ, Zhou D, Xiao L, Zhou L, Li Y, Bastacky SI, Oury TD, Liu Y. Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease. J Am Soc Nephrol. 2015 Oct;26(10):2447-59. doi: 10.1681/ASN.2014060613. Epub 2015 Feb 2.PMID: 25644107

Tan RJ, Liu Y. Macrophage-derived TGF-β in renal fibrosis: not a macro-impact after all. Am J Physiol Renal Physiol. 2013 Sep 15;305(6):F821-2. doi: 10.1152/ajprenal.00356.2013. Epub 2013 Jul 3. No abstract available. PMID: 23825074

Zhou D, Tan RJ, Lin L, Zhou L, Liu Y. Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury. Kidney Int. 2013 Sep;84(3):509-20. doi: 10.1038/ki.2013.102. Epub 2013 May 29. PMID: 23715119

Zhou D, Tan RJ, Zhou L, Li Y, Liu Y. Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication. Sci Rep. 2013;3:1878. doi: 10.1038/srep01878.PMID: 23698793

He W, Tan RJ, Li Y, Wang D, Nie J, Hou FF, Liu Y. Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/β-catenin activity in CKD. J Am Soc Nephrol. 2012 Feb;23(2):294-304. doi: 10.1681/ASN.2011050490. Epub 2011 Nov 17. PMID:2209594

Full List of Publications