Research Interest Summary
The Dermody laboratory studies the molecular pathogenesis of mammalian reovirus and Chikungunya virus infections. Reovirus is an enteric, neurotropic virus that infects many mammalian species, including humans, but the disease is restricted to the very young. Chikungunya virus (CHIKV) is an emerging arthropod-borne alphavirus that causes epidemics of febrile arthritis in humans. To learn more about new CHIKV projects, please contact the Silva Lab (Laurie.Silva@pitt.edu).
Ongoing research in the Dermody laboratory encompasses several interrelated themes to better understand viral and cellular mediators of disease. These include the structural basis of viral attachment and entry into cells, mechanisms of genome replication and packaging, patterns of cell signaling and gene expression occurring in response to viral infection, mechanisms of virus-induced apoptosis and its significance in the viral life cycle, and roles of viral receptor distribution and utilization in disease pathology. We also are developing viral vectors for oncolytic and vaccine applications.
Barton, E. S., Forrest, J. C., Connolly, J. L., Chappell, J. D., Liu, Y., Schnell, F. J., Nusrat, A., Parkos, C. A., and T. S. Dermody. Junction adhesion molecule is a receptor for reovirus. Cell 104:441-451, 2001. PMID: 11239401
Ebert, D. H., Deussing, J., Peters, C., and T. S. Dermody. Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblasts. J. Biol. Chem. 277:24609-24617, 2002. PMID: 11986312
O'Donnell, S. M., Connolly, J. L., Hansberger, M. W., Chappell, J. D., Watson, M. J., Han, W., Barton, E. S., Forrest, J. C., Valyi-Nagy, T., Pierce, J. M., Yull, F. E., Blackwell, T. S., Rottman, J. N., Sherry, B. J., and T. S. Dermody. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J. Clin. Invest. 115:2341-2350, 2005. PMCID: PMC1184036
Kirchner, E., Guglielmi, K. M., Strauss, H., Dermody, T. S., and T. Stehle. Structure of reovirus sigma 1 in complex with its receptor junctional adhesion molecule-A. PLoS Pathog. 4:e1000235, 2008. PMCID: PMC2588538
Antar, A. A. R., Konopka, J. L., Campbell, J. A., Henry, R. A., Perdigoto, A. L., Carter, B. D., Pozzi, A., Abel, T. W., and T. S. Dermody. Junctional adhesion molecule-A is required for hematogenous dissemination of reovirus. Cell Host Microbe. 5:59-71, 2009. PMCID: PMC2642927
Danthi, P., Pruijssers, A. J., Berger, A. K., Holm, G. H., Zinkel, S. S., and T. S. Dermody. Bid regulates the pathogenesis of neurotropic reovirus. PLoS Pathog. 6:e1000980, 2010. PMCID: PMC2895667
Konopka-Anstadt, J. L., Mainou, B. A., Sutherland, D. M., Sekine, Y., Strittmatter, S. M., and T. S. Dermody. The Nogo receptor NgR1 mediates infection by mammalian reovirus. Cell Host Microbe. 15:681-691, 2014. PMCID: PMC4100558
Doyle, J. D., Stencel-Baerenwald, J. E., Copeland, C. A., Rhoads, J. P., Brown, J. J., Boyd, K. L., Atkinson, J. B., and T. S. Dermody. Diminished reovirus capsid stability alters disease pathogenesis and littermate transmission. PLoS Pathog. 11:e1004693, 2015. PMCID: PMC4349883
Ashbrook, A. W., Lentscher, A. J., Zamora, P. F., Silva, L. A., May, N. A., Bauer, J. A., Morrison, T. E., and T. S. Dermody. Antagonism of the sodium-potassium ATPase impairs chikungunya virus infection. mBio 7:e00693-16, 2016. PMCID: PMC4895112
Bouziat, R., Hinterleitner, R., Brown, J. J., […], Dermody, T. S., and B. Jabri. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 356:44-50, 2017. PMCID: PMC5506690